Daniel Martinez Lara, widely known as Pepeland, has made some changes in the default Blender UI layout and made it available for download.
It is important to notice that these are not structural changes. Everything he made was using the native customization capabilities of Blender. This UI layout makes Blender a bit more familiar for the ones used to the 3DSMax interface.
Take a look at the video below, where he uses Blender with this custom layout, showing a great modification of Suzanne and also dealing with a niiiice animation made by him on the Video Sequence Editor. That's a guy who knows what he's doing... ;)
Pepeland Blender Interface from pepeland on Vimeo.
It's a really nice animation. And the use of Grease Pencil is also great.
Talking about interface, have you seen the UI Willian presented in BConference?
Probably Blender 2.50 will follow something in this direction:
http://reynish.com/blender_ui/blender_25_ui.png
Abração Virgílio
Yes, Daniel knows very well the tips and the practicality of the 3D tools and he's take advantage of that in the animations.